The NatWest bank has announced plans to close its Bankside branch in Southwark Street and its Tower Bridge branch in Tooley Street.
The Bankside branch opened just four years ago when NatWest's parent company RBS occupied the offices above.
The Tower Bridge branch of NatWest occupies a grade II listed building on the corner of Tooley Street and Tower Bridge Road.
It was built in 1900 for the London & County Bank, which had its roots in Southwark in 1836.
The branch closures will leave NatWest with just two branches in SE1, at Lambeth North and London Bridge.
For the latest local news and events direct to your inbox every Monday, you need our weekly email newsletter SE1 Direct.