The 17 bus routes that run along Waterloo Road will be subject to overnight diversions every night this week whilst Network Rail strengthens the bridge that carries the Charing Cross to Waterloo East line over the road.
The northern section of Waterloo Road will be closed every night between 10.30pm and 5am until Monday 14 April.
The road closure affects bus routes 1, 4, 26, 59, 68, 76, 168, 171, 172, 176, 188, 341, X68, N1, N68, N76 and N171.
All those routes will be diverted via York Road and Westminster Bridge Road.
Alaska Street – which links Waterloo Road with Cornwall Road – is closed for 35 weeks as part of the same programme of bridge works.
For the latest local news and events direct to your inbox every Monday, you need our weekly email newsletter SE1 Direct.