Hercules Road was closed to traffic on Friday lunchtime as firefighters tackled a fire in a house near the junction with Virgil Street.
The London Fire Brigade was called to the scene at 1.28pm to reports of smoke coming from the three-storey house.
Fire engines from Lambeth and Old Kent Road fire stations were dispatched and the blaze was under control within 20 minutes.
A brigade spokeswoman told the London SE1 website that the cause of the fire is under investigation.
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