A branch of The Co-operative Food and a Carluccio's restaurant are to open at the Neo Bankside development.
The Co-operative Food has applied for a premises licence for the ground floor of Pavilion D, close to the corner of Sumner Street and Southwark Street.
The new Co-operative Food store will be just 120 metres from Sainsbury's Local and Tesco Express in Great Suffolk Street and 215 metres from M&S Simply Food in Southwark Street.
Meanwhile Carluccio's is to open a restaurant in Pavilion A on Holland Street, the block closest to the main entrance of Tate Modern.
Last year developers Native Land and Singapore's Hwa Hong Corporation spent more than £10 million acquring a 999 year lease on the retail space at Neo Bankside.
At the time Alasdair Nicholls, chief executive of Native Land, said: "We are offering retailers the opportunity to occupy a key site at the very epicentre of this dynamic and ever evolving neighbourhood."
Currently only the retail space at Pavilion B – Sir Terence Conran's Albion restaurant – is occupied.
In April 2014 one of the penthouses at Neo Bankside was advertised for sale at £22 million.
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