The new Premier Inn being built on land next to Southwark College in The Cut was last week 'topped out' as construction work reached its highest point.
Construction of the building started in July last year, and the Premier Inn and Bar + Block Steakhouse are expected to open in autumn 2020.
"We're delighted to be celebrating this milestone with Whitbread and LaSalle and are excited to be a part of helping to grow the Premier Inn network across the Capital," said Jo Allen, Frogmore's chief executive.
"The hotel should be a welcome contribution to the vibrant Southwark scene; with the addition of the Bar + Block Steakhouse, as well as the additional open space for public enjoyment."
Whitbread's Jonathan Langdon added: "The creation of high-quality local jobs was an important consideration in the planning case for New Marlborough Yard.
"With the development now topping out we are one step closer to recruiting for the 70 new roles on offer in the Premier Inn and Bar + Block Steakhouse.
"Our approach is to recruit locally for all new Premier Inn hotels and we hope residents living in the local area will be interested in applying as we get closer to opening what will be one of our flagship hotels in Central London."
Frogmore secured a forward funding investment sale of the development worth £85 million from LaSalle, investing on behalf of Greater Manchester Pension Fund.
Tom Rose from LaSalle said: "We're delighted to be celebrating the topping out of this development, which is situated in one of the most attractive areas of central London.
"The asset has very strong fundamentals and offers a fantastic return profile to our client given Premier Inn's long‐term lease with inflation‐linked uplifts."
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